"[N]ew Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness."

Most likely!

Seems most likely...

That's almost devil-may-care! Are we playing the odds here?

What if some big project today, something much less momentous than an all-new government — let's say Obamacare — were presented on the theory that it seems most likely to make us safe and happy.

You'd scream no, wouldn't you? You'd blog/comment with derision and contempt at the dangerousness of radical change. Wouldn't you?

"[T]hey are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty and the pursuit of Happiness."

Among these...

So there are others.

What other inalienable rights would you like to call to our attention today?

"[A] decent respect to the opinions of mankind requires that they should declare the causes which impel them to the separation."

Does a decent respect for the opinions of mankind ever impel you to declare anything?

"Prudence, indeed, will dictate that Governments long established should not be changed for light and transient causes..."

"... and accordingly all experience hath shown, that mankind are more disposed to suffer, while evils are sufferable, than to right themselves by abolishing the forms to which they are accustomed."

"Reading The Declaration Of Independence Aloud..."

NPR does a nice job of.